Definition: By Mayo Clinic staff
Wegener’s granulomatosis (VEG-eh-nerz gran-u-loe-muh-TOE-sis) is an uncommon disorder that causes inflammation of your blood vessels. This inflammation restricts blood flow to various organs.
Wegener’s granulomatosis, which is also called granulomatosis with polyangiitis (GPA), often affects your kidneys, lungs and upper respiratory tract. The restricted blood flow to these organs can damage them. Wegener’s can affect other organs, but this isn’t as common, and generally isn’t as serious.
Wegener’s granulomatosis also produces a type of inflammatory tissue known as a granuloma that’s found around the blood vessels. Granulomas can destroy normal tissue. There is no known cause for Wegener’s granulomatosis.
Early diagnosis and treatment of Wegener’s granulomatosis may lead to [remission]. Without treatment, Wegener’s granulomatosis can be fatal, most commonly from kidney failure.
For more information visit: The Mayo Clinic
For information and resources regarding vasculitis diseases visit: The Vasculitis Foundation
For information and resources regarding all rare diseases visit: The National Organization of Rare Disorders
Update: In an effort to improve the understanding of Wegener’s granulomatosis, the name is being changed to Granulomatosis with Polyangitis (GPA).